Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively. [provided by RefSeq, Jan 2010]
Transcription factors with Perturb-seq knockdown data for COX6B1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COX6B1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COX6B1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:35,471,034–35,471,539 | 177.0 kb | Distal (>10kb) Multiome | 15 | |
| chr19:35,509,786–35,510,900 | 137.8 kb | Distal (>10kb) Multiome | 650 | |
| chr19:35,545,067–35,546,126 | 102.7 kb | Distal (>10kb) Multiome | 879 | |
| chr19:35,557,343–35,558,684 | 90.2 kb | Distal (>10kb) Multiome | 452 | |
| chr19:35,612,546–35,613,176 | 35.6 kb | Distal (>10kb) Multiome | 778 | |
| chr19:35,628,465–35,629,474 | 19.4 kb | Distal (>10kb) Multiome | 889 | |
| chr19:35,641,602–35,642,192 | 6.6 kb | Proximal (<10kb) Multiome | 183 | |
| chr19:35,643,064–35,645,730 | 4.8 kb | Proximal (<10kb) Multiome | 1010 | |
| chr19:35,648,040–35,648,575 | 113 bp | At TSS Multiome | 599 | |
| chr19:35,673,179–35,673,643 | 25.1 kb | Distal (>10kb) Multiome | 311 | |
| chr19:35,702,152–35,702,985 | 54.2 kb | Distal (>10kb) Multiome | 662 | |
| chr19:35,716,025–35,718,811 | 69.4 kb | Distal (>10kb) Multiome | 1018 | |
| chr19:35,740,083–35,741,430 | 92.5 kb | Distal (>10kb) Multiome | 829 | |
| chr19:35,744,481–35,746,086 | 97.0 kb | Distal (>10kb) Multiome | 679 | |
| chr19:35,748,170–35,749,017 | 100.1 kb | Distal (>10kb) Multiome | 749 | |
| chr19:35,757,432–35,758,657 | 109.8 kb | Distal (>10kb) Multiome | 851 | |
| chr19:35,767,601–35,768,256 | 119.6 kb | Distal (>10kb) Multiome | 276 | |
| chr19:35,775,066–35,776,063 | 127.1 kb | Distal (>10kb) Multiome | 474 | |
| chr19:35,784,357–35,785,306 | 136.4 kb | Distal (>10kb) Multiome | 183 | |
| chr19:35,860,621–35,861,651 | 213.0 kb | Distal (>10kb) Multiome | 299 | |
| chr19:35,868,369–35,868,860 | 220.2 kb | Distal (>10kb) Multiome | 320 | |
| chr19:35,869,343–35,870,482 | 221.6 kb | Distal (>10kb) Multiome | 492 | |
| chr19:35,899,240–35,900,760 | 251.4 kb | Distal (>10kb) Multiome | 751 | |
| chr19:35,931,342–35,932,167 | 283.3 kb | Distal (>10kb) Multiome | 835 | |
| chr19:35,936,083–35,936,704 | 288.1 kb | Distal (>10kb) Multiome | 417 |
Genomic view of the COX6B1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.