COL23A1 is a member of the transmembrane collagens, a subfamily of the nonfibrillar collagens that contain a single pass hydrophobic transmembrane domain (Banyard et al., 2003 [PubMed 12644459]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for COL23A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COL23A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COL23A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:178,231,971–178,233,141 | 344.9 kb | Distal (>10kb) Multiome HiCAR | 764 | |
| chr5:178,470,038–178,470,701 | 107.0 kb | Distal (>10kb) Multiome | 49 | |
| chr5:178,563,529–178,564,357 | 13.5 kb | Distal (>10kb) Multiome | 28 | |
| chr5:178,565,213–178,565,920 | 12.0 kb | Distal (>10kb) Multiome | 25 | |
| chr5:178,576,579–178,577,785 | at TSS | At TSS | 147 | |
| chr5:178,589,202–178,590,958 | 13.0 kb | Distal (>10kb) Multiome | 378 | |
| chr5:178,626,153–178,627,627 | 49.6 kb | Distal (>10kb) Multiome | 927 | |
| chr5:178,730,157–178,730,973 | 153.2 kb | Distal (>10kb) Multiome | 717 | |
| chr5:178,778,843–178,779,399 | 201.5 kb | Distal (>10kb) Multiome | 165 | |
| chr5:178,859,723–178,860,476 | 282.4 kb | Distal (>10kb) Multiome | 813 |
Genomic view of the COL23A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.