Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for CLTA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLTA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLTA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:36,036,454–36,037,604 | 153.9 kb | Distal (>10kb) Multiome | 528 | |
| chr9:36,118,241–36,119,014 | 72.5 kb | Distal (>10kb) Multiome | 47 | |
| chr9:36,135,958–36,137,395 | 54.3 kb | Distal (>10kb) Multiome | 462 | |
| chr9:36,163,065–36,163,901 | 27.5 kb | Distal (>10kb) Multiome | 343 | |
| chr9:36,166,123–36,166,839 | 24.3 kb | Distal (>10kb) Multiome | 515 | |
| chr9:36,188,047–36,188,562 | 2.5 kb | Proximal (<10kb) Multiome | 13 | |
| chr9:36,190,095–36,190,219 | 700 bp | At TSS | 60 | |
| chr9:36,190,463–36,191,342 | 121 bp | At TSS Multiome | 863 | |
| chr9:36,257,896–36,258,893 | 67.4 kb | Distal (>10kb) Multiome | 891 | |
| chr9:36,400,210–36,402,094 | 210.1 kb | Distal (>10kb) Multiome | 864 | |
| chr9:36,415,916–36,416,528 | 225.3 kb | Distal (>10kb) Multiome | 55 | |
| chr9:36,486,561–36,488,558 | 296.9 kb | Distal (>10kb) Multiome | 733 |
Genomic view of the CLTA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.