Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CLIC4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLIC4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLIC4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:24,502,196–24,503,523 | 242.5 kb | Distal (>10kb) Multiome | 663 | |
| chr1:24,506,950–24,507,727 | 238.2 kb | Distal (>10kb) Multiome | 119 | |
| chr1:24,642,448–24,643,922 | 102.2 kb | Distal (>10kb) Multiome | 942 | |
| chr1:24,705,111–24,705,985 | 39.9 kb | Distal (>10kb) Multiome | 599 | |
| chr1:24,713,638–24,714,105 | 31.5 kb | Distal (>10kb) Multiome | 23 | |
| chr1:24,724,528–24,725,933 | 20.7 kb | Distal (>10kb) Multiome | 603 | |
| chr1:24,736,028–24,736,394 | 9.0 kb | Proximal (<10kb) | 229 | |
| chr1:24,742,136–24,742,833 | 2.9 kb | Proximal (<10kb) Multiome | 326 | |
| chr1:24,744,531–24,746,080 | 161 bp | At TSS Multiome | 964 | |
| chr1:24,847,777–24,848,804 | 102.8 kb | Distal (>10kb) Multiome | 854 | |
| chr1:24,929,080–24,930,934 | 185.0 kb | Distal (>10kb) Multiome | 414 | |
| chr1:24,931,551–24,932,717 | 187.0 kb | Distal (>10kb) Multiome | 362 |
Genomic view of the CLIC4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.