This gene encodes a member of the CHIC family of proteins. The encoded protein contains a cysteine-rich hydrophobic (CHIC) motif, and is localized to vesicular structures and the plasma membrane. This gene is associated with some cases of acute myeloid leukemia. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CHIC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHIC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHIC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:53,919,576–53,920,578 | 144.4 kb | Distal (>10kb) Multiome | 149 | |
| chr4:53,923,917–53,924,791 | 140.3 kb | Distal (>10kb) Multiome | 114 | |
| chr4:54,015,559–54,016,024 | 48.8 kb | Distal (>10kb) Multiome | 97 | |
| chr4:54,063,729–54,065,237 | 56 bp | At TSS Multiome | 809 | |
| chr4:54,065,973–54,066,176 | 1.4 kb | Proximal (<10kb) | 52 | |
| chr4:54,066,651–54,067,574 | 2.4 kb | Proximal (<10kb) Multiome | 296 | |
| chr4:54,099,424–54,101,068 | 35.4 kb | Distal (>10kb) Multiome | 200 | |
| chr4:54,103,204–54,104,370 | 39.1 kb | Distal (>10kb) Multiome | 120 | |
| chr4:54,197,150–54,197,872 | 132.9 kb | Distal (>10kb) Multiome | 125 | |
| chr4:54,215,002–54,215,966 | 151.0 kb | Distal (>10kb) Multiome HiCAR | 130 | |
| chr4:54,217,474–54,218,395 | 153.3 kb | Distal (>10kb) Multiome HiCAR | 422 | |
| chr4:54,226,597–54,228,751 | 162.3 kb | Distal (>10kb) Multiome HiCAR | 426 | |
| chr4:54,229,771–54,234,753 | 168.6 kb | Distal (>10kb) Multiome | 713 |
Genomic view of the CHIC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.