Transcription factors with Perturb-seq knockdown data for CEACAM16-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEACAM16-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEACAM16-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:44,499,680–44,500,955 | 218.2 kb | Distal (>10kb) Multiome | 1007 | |
| chr19:44,643,571–44,644,620 | 74.8 kb | Distal (>10kb) Multiome | 710 | |
| chr19:44,723,776–44,724,180 | 5.0 kb | Proximal (<10kb) | 441 | |
| chr19:44,747,085–44,747,789 | 28.8 kb | Distal (>10kb) Multiome | 653 | |
| chr19:44,758,633–44,759,104 | 40.2 kb | Distal (>10kb) Multiome | 80 | |
| chr19:44,770,589–44,771,108 | 52.0 kb | Distal (>10kb) Multiome | 367 | |
| chr19:44,777,671–44,778,314 | 59.1 kb | Distal (>10kb) Multiome | 353 | |
| chr19:44,800,231–44,800,829 | 81.8 kb | Distal (>10kb) Multiome | 508 | |
| chr19:44,807,965–44,809,338 | 89.5 kb | Distal (>10kb) Multiome | 652 | |
| chr19:44,844,448–44,848,668 | 127.3 kb | Distal (>10kb) Multiome | 1047 | |
| chr19:44,890,209–44,891,796 | 172.2 kb | Distal (>10kb) Multiome | 952 | |
| chr19:44,905,114–44,907,037 | 187.9 kb | Distal (>10kb) Multiome | 645 | |
| chr19:44,913,546–44,915,671 | 196.4 kb | Distal (>10kb) Multiome | 587 | |
| chr19:44,926,693–44,927,388 | 208.5 kb | Distal (>10kb) Multiome | 277 | |
| chr19:44,954,641–44,955,824 | 236.5 kb | Distal (>10kb) Multiome | 835 | |
| chr19:45,001,031–45,002,639 | 283.2 kb | Distal (>10kb) Multiome | 694 |
Genomic view of the CEACAM16-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.