The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for CDK17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDK17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDK17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:96,193,825–96,194,736 | 206.1 kb | Distal (>10kb) Multiome | 537 | |
| chr12:96,215,259–96,215,740 | 185.0 kb | Distal (>10kb) Multiome | 518 | |
| chr12:96,256,842–96,257,316 | 143.3 kb | Distal (>10kb) Multiome | 52 | |
| chr12:96,372,974–96,373,613 | 27.2 kb | Distal (>10kb) Multiome | 45 | |
| chr12:96,399,206–96,401,284 | 11 bp | At TSS Multiome | 864 | |
| chr12:96,428,927–96,429,448 | 28.7 kb | Distal (>10kb) Multiome HiCAR | 179 | |
| chr12:96,489,370–96,490,086 | 89.1 kb | Distal (>10kb) Multiome | 618 |
Genomic view of the CDK17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.