CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. This protein is secreted and is primarily found in bone marrow. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CDC42EP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDC42EP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDC42EP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:37,419,824–37,420,580 | 140.2 kb | Distal (>10kb) Multiome | 150 | |
| chr22:37,518,831–37,519,884 | 41.0 kb | Distal (>10kb) Multiome | 548 | |
| chr22:37,545,569–37,546,885 | 14.1 kb | Distal (>10kb) Multiome | 682 | |
| chr22:37,559,893–37,560,965 | 125 bp | At TSS Multiome | 589 | |
| chr22:37,561,648–37,562,035 | 1.2 kb | Proximal (<10kb) | 719 | |
| chr22:37,567,378–37,567,600 | 6.9 kb | Proximal (<10kb) | 419 | |
| chr22:37,569,013–37,570,549 | 9.0 kb | Proximal (<10kb) Multiome | 695 | |
| chr22:37,608,044–37,609,455 | 48.3 kb | Distal (>10kb) Multiome | 920 | |
| chr22:37,639,157–37,639,951 | 79.1 kb | Distal (>10kb) Multiome | 427 | |
| chr22:37,658,172–37,659,508 | 98.1 kb | Distal (>10kb) Multiome | 722 | |
| chr22:37,674,916–37,675,641 | 114.9 kb | Distal (>10kb) Multiome | 607 | |
| chr22:37,676,590–37,677,674 | 116.8 kb | Distal (>10kb) Multiome | 655 | |
| chr22:37,686,104–37,686,784 | 125.9 kb | Distal (>10kb) Multiome | 866 | |
| chr22:37,696,496–37,697,685 | 136.4 kb | Distal (>10kb) Multiome | 428 | |
| chr22:37,745,641–37,746,995 | 185.7 kb | Distal (>10kb) Multiome | 627 | |
| chr22:37,802,124–37,802,989 | 241.9 kb | Distal (>10kb) Multiome | 603 | |
| chr22:37,804,679–37,805,768 | 244.8 kb | Distal (>10kb) Multiome | 763 | |
| chr22:37,807,436–37,808,267 | 247.3 kb | Distal (>10kb) Multiome | 766 | |
| chr22:37,817,672–37,819,114 | 257.4 kb | Distal (>10kb) Multiome | 713 | |
| chr22:37,824,524–37,825,593 | 264.5 kb | Distal (>10kb) Multiome | 173 | |
| chr22:37,843,748–37,844,743 | 283.9 kb | Distal (>10kb) Multiome | 798 | |
| chr22:37,849,215–37,849,709 | 288.9 kb | Distal (>10kb) Multiome | 753 |
Genomic view of the CDC42EP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.