CDC25C

cell division cycle 25C | PPP1R60, CDC25

This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015]

Member of: DE-11 DE-11.1 Developmental clusters: GC4

Biological processes 28 terms

G2/M transition of mitotic cell cycle (GO:0000086)G2/M transition of mitotic cell cycle (GO:0000086)G2/M transition of mitotic cell cycle (GO:0000086)G2/M transition of mitotic cell cycle (GO:0000086)WW domain binding (GO:0050699)cell population proliferation (GO:0008283)cell population proliferation (GO:0008283)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)mitochondrial intermembrane space (GO:0005758)nuclear speck (GO:0016607)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)phosphoprotein phosphatase activity (GO:0004721)positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)positive regulation of G2/MI transition of meiotic cell cycle (GO:0110032)positive regulation of cell cycle G2/M phase transition (GO:1902751)protein binding (GO:0005515)protein kinase binding (GO:0019901)protein serine/threonine kinase binding (GO:0120283)protein tyrosine phosphatase activity (GO:0004725)protein tyrosine phosphatase activity (GO:0004725)protein tyrosine phosphatase activity (GO:0004725)regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)regulation of mitotic nuclear division (GO:0007088)

Expression (TPM)

TFs regulating CDC25C 0 TFs

Transcription factors with Perturb-seq knockdown data for CDC25C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDC25C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CDC25C

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDC25C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr5:138,032,174–138,033,856	298.7 kb	Distal (>10kb) Multiome	889
chr5:138,036,018–138,036,514	295.6 kb	Distal (>10kb) Multiome	359
chr5:138,095,141–138,095,876	236.4 kb	Distal (>10kb) Multiome	194
chr5:138,178,349–138,179,428	152.9 kb	Distal (>10kb) Multiome	789
chr5:138,212,899–138,214,126	118.3 kb	Distal (>10kb) Multiome	747
chr5:138,241,684–138,242,313	89.8 kb	Distal (>10kb) Multiome	397
chr5:138,247,699–138,248,212	83.8 kb	Distal (>10kb) Multiome	13
chr5:138,274,126–138,274,706	57.4 kb	Distal (>10kb) Multiome	161
chr5:138,331,426–138,332,354	143 bp	At TSS Multiome	686
chr5:138,337,358–138,339,397	6.4 kb	Proximal (<10kb) Multiome	1134
chr5:138,352,125–138,353,730	20.8 kb	Distal (>10kb) Multiome	868
chr5:138,438,317–138,439,353	107.2 kb	Distal (>10kb) Multiome	421
chr5:138,449,690–138,450,452	118.3 kb	Distal (>10kb) Multiome	486
chr5:138,463,424–138,467,199	133.4 kb	Distal (>10kb) Multiome	1117
chr5:138,489,025–138,489,656	157.6 kb	Distal (>10kb) Multiome	185
chr5:138,491,730–138,492,628	160.3 kb	Distal (>10kb) Multiome	627
chr5:138,542,539–138,543,997	211.5 kb	Distal (>10kb) Multiome	973
chr5:138,574,967–138,576,411	243.9 kb	Distal (>10kb) Multiome	1066

Genome Browser

Genomic view of the CDC25C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.