Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in G1/S transition of mitotic cell cycle. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CCNJ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCNJ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCNJ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:95,840,547–95,841,469 | 202.7 kb | Distal (>10kb) Multiome | 21 | |
| chr10:95,907,059–95,908,292 | 135.7 kb | Distal (>10kb) Multiome | 823 | |
| chr10:95,920,289–95,921,295 | 123.0 kb | Distal (>10kb) Multiome | 99 | |
| chr10:96,039,077–96,039,383 | 4.2 kb | Proximal (<10kb) | 72 | |
| chr10:96,043,065–96,044,649 | 49 bp | At TSS Multiome | 891 | |
| chr10:96,129,440–96,130,826 | 86.6 kb | Distal (>10kb) Multiome | 1039 | |
| chr10:96,309,703–96,310,258 | 266.5 kb | Distal (>10kb) Multiome | 187 | |
| chr10:96,324,253–96,324,992 | 281.0 kb | Distal (>10kb) Multiome | 66 |
Genomic view of the CCNJ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.