The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CAVIN3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAVIN3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAVIN3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:6,234,062–6,235,769 | 85.6 kb | Distal (>10kb) Multiome | 776 | |
| chr11:6,237,822–6,239,512 | 81.6 kb | Distal (>10kb) Multiome | 164 | |
| chr11:6,249,589–6,250,614 | 70.5 kb | Distal (>10kb) Multiome | 268 | |
| chr11:6,251,174–6,251,654 | 69.1 kb | Distal (>10kb) Multiome | 193 | |
| chr11:6,258,709–6,260,456 | 60.8 kb | Distal (>10kb) Multiome | 283 | |
| chr11:6,267,833–6,269,111 | 52.0 kb | Distal (>10kb) Multiome | 142 | |
| chr11:6,280,060–6,282,351 | 39.7 kb | Distal (>10kb) Multiome | 214 | |
| chr11:6,315,706–6,316,120 | 4.4 kb | Proximal (<10kb) | 234 | |
| chr11:6,318,947–6,321,304 | 482 bp | At TSS Multiome | 591 | |
| chr11:6,323,135–6,324,040 | 2.6 kb | Proximal (<10kb) | 99 | |
| chr11:6,326,319–6,326,654 | 5.8 kb | Proximal (<10kb) | 9 | |
| chr11:6,353,367–6,353,932 | 33.1 kb | Distal (>10kb) Multiome | 395 | |
| chr11:6,367,341–6,367,799 | 47.0 kb | Distal (>10kb) Multiome | 55 | |
| chr11:6,389,605–6,390,990 | 69.8 kb | Distal (>10kb) Multiome | 752 | |
| chr11:6,405,086–6,405,670 | 84.9 kb | Distal (>10kb) Multiome | 99 | |
| chr11:6,418,399–6,419,618 | 98.6 kb | Distal (>10kb) Multiome | 494 | |
| chr11:6,468,896–6,469,642 | 148.8 kb | Distal (>10kb) Multiome | 253 | |
| chr11:6,473,129–6,474,612 | 153.5 kb | Distal (>10kb) Multiome | 591 | |
| chr11:6,480,885–6,482,114 | 160.9 kb | Distal (>10kb) Multiome | 828 | |
| chr11:6,496,967–6,497,550 | 176.8 kb | Distal (>10kb) Multiome | 71 | |
| chr11:6,586,489–6,587,591 | 266.5 kb | Distal (>10kb) Multiome | 231 | |
| chr11:6,603,192–6,604,726 | 283.2 kb | Distal (>10kb) Multiome | 908 | |
| chr11:6,606,600–6,607,433 | 286.6 kb | Distal (>10kb) Multiome | 532 | |
| chr11:6,611,505–6,613,097 | 291.8 kb | Distal (>10kb) Multiome | 996 | |
| chr11:6,618,753–6,619,738 | 298.9 kb | Distal (>10kb) Multiome | 587 |
Genomic view of the CAVIN3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.