This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for BUB1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BUB1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BUB1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:39,888,792–39,889,226 | 272.1 kb | Distal (>10kb) Multiome | 62 | |
| chr15:39,920,609–39,921,284 | 240.1 kb | Distal (>10kb) Multiome | 707 | |
| chr15:39,933,904–39,934,437 | 226.9 kb | Distal (>10kb) Multiome | 698 | |
| chr15:40,038,862–40,039,388 | 121.8 kb | Distal (>10kb) Multiome | 750 | |
| chr15:40,108,639–40,109,491 | 52.0 kb | Distal (>10kb) Multiome | 798 | |
| chr15:40,155,366–40,155,641 | 5.4 kb | Proximal (<10kb) | 136 | |
| chr15:40,160,791–40,161,326 | 14 bp | At TSS Multiome | 762 | |
| chr15:40,323,099–40,324,127 | 162.5 kb | Distal (>10kb) Multiome | 737 | |
| chr15:40,357,707–40,358,772 | 197.2 kb | Distal (>10kb) Multiome | 515 | |
| chr15:40,367,875–40,368,398 | 207.2 kb | Distal (>10kb) Multiome | 846 | |
| chr15:40,405,523–40,406,103 | 244.7 kb | Distal (>10kb) Multiome | 672 | |
| chr15:40,440,664–40,441,222 | 279.9 kb | Distal (>10kb) Multiome | 440 |
Genomic view of the BUB1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.