This gene encodes an adaptor protein that belongs to the bicaudal D family of dynein cargo adaptors. The encoded protein acts as an intracellular cargo transport cofactor that regulates the microtubule-based loading of cargo onto the dynein motor complex. It also controls dynein motor activity and coordination. It has a domain architecture consisting of coiled-coil domains at the N- and C-termini that are highly conserved in other family members. Naturally occurring mutations in this gene are associated with short telomere length and emphysema. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for BICD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BICD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BICD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:31,659,057–31,659,786 | 447.5 kb | Distal (>10kb) Multiome HiCAR | 737 | |
| chr12:31,896,572–31,897,018 | 210.0 kb | Distal (>10kb) Multiome | 385 | |
| chr12:31,958,831–31,959,907 | 147.5 kb | Distal (>10kb) Multiome | 866 | |
| chr12:31,966,416–31,967,293 | 140.0 kb | Distal (>10kb) Multiome | 118 | |
| chr12:32,016,824–32,017,328 | 89.7 kb | Distal (>10kb) Multiome | 159 | |
| chr12:32,022,349–32,022,802 | 84.2 kb | Distal (>10kb) Multiome | 56 | |
| chr12:32,047,438–32,048,247 | 58.9 kb | Distal (>10kb) Multiome | 272 | |
| chr12:32,106,218–32,107,295 | 67 bp | At TSS Multiome | 874 | |
| chr12:32,139,428–32,140,190 | 33.1 kb | Distal (>10kb) Multiome | 274 | |
| chr12:32,398,922–32,400,774 | 292.8 kb | Distal (>10kb) Multiome | 832 |
Genomic view of the BICD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.