This gene encodes a branched chain aminotransferase found in mitochondria. The encoded protein forms a dimer that catalyzes the first step in the production of the branched chain amino acids leucine, isoleucine, and valine. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Transcription factors with Perturb-seq knockdown data for BCAT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BCAT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BCAT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:48,510,624–48,511,212 | 300.3 kb | Distal (>10kb) Multiome | 268 | |
| chr19:48,513,480–48,514,294 | 297.1 kb | Distal (>10kb) Multiome | 585 | |
| chr19:48,614,318–48,615,255 | 196.1 kb | Distal (>10kb) Multiome | 524 | |
| chr19:48,618,726–48,619,869 | 191.7 kb | Distal (>10kb) Multiome | 1012 | |
| chr19:48,623,839–48,624,688 | 186.8 kb | Distal (>10kb) Multiome | 529 | |
| chr19:48,629,369–48,631,306 | 181.0 kb | Distal (>10kb) Multiome | 402 | |
| chr19:48,634,242–48,636,244 | 175.3 kb | Distal (>10kb) Multiome | 868 | |
| chr19:48,636,802–48,639,603 | 172.6 kb | Distal (>10kb) Multiome | 956 | |
| chr19:48,645,454–48,647,163 | 164.5 kb | Distal (>10kb) Multiome HiCAR | 750 | |
| chr19:48,675,421–48,675,873 | 135.5 kb | Distal (>10kb) Multiome | 415 | |
| chr19:48,695,830–48,697,033 | 114.9 kb | Distal (>10kb) Multiome | 253 | |
| chr19:48,713,646–48,714,846 | 96.7 kb | Distal (>10kb) Multiome | 719 | |
| chr19:48,716,551–48,717,038 | 94.1 kb | Distal (>10kb) Multiome | 241 | |
| chr19:48,720,420–48,721,301 | 90.1 kb | Distal (>10kb) Multiome | 689 | |
| chr19:48,735,001–48,735,602 | 75.8 kb | Distal (>10kb) Multiome | 161 | |
| chr19:48,738,441–48,739,812 | 72.1 kb | Distal (>10kb) Multiome | 743 | |
| chr19:48,741,194–48,741,939 | 69.5 kb | Distal (>10kb) Multiome | 350 | |
| chr19:48,746,830–48,747,395 | 63.9 kb | Distal (>10kb) Multiome | 402 | |
| chr19:48,752,314–48,753,547 | 58.1 kb | Distal (>10kb) Multiome | 545 | |
| chr19:48,795,165–48,795,736 | 15.5 kb | Distal (>10kb) Multiome | 724 | |
| chr19:48,806,734–48,807,478 | 4.1 kb | Proximal (<10kb) Multiome | 452 | |
| chr19:48,810,774–48,811,494 | 2 bp | At TSS Multiome | 662 | |
| chr19:48,812,048–48,813,099 | 1.5 kb | Proximal (<10kb) Multiome | 603 | |
| chr19:48,829,998–48,830,690 | 19.3 kb | Distal (>10kb) Multiome | 55 | |
| chr19:48,835,571–48,838,073 | 24.8 kb | Distal (>10kb) Multiome | 621 | |
| chr19:48,872,000–48,873,835 | 61.3 kb | Distal (>10kb) Multiome | 987 | |
| chr19:48,895,958–48,896,628 | 85.3 kb | Distal (>10kb) Multiome | 207 | |
| chr19:48,899,782–48,900,620 | 89.2 kb | Distal (>10kb) Multiome | 710 | |
| chr19:48,933,397–48,933,948 | 122.6 kb | Distal (>10kb) Multiome | 458 | |
| chr19:48,954,440–48,955,356 | 143.8 kb | Distal (>10kb) Multiome | 905 | |
| chr19:48,963,322–48,964,187 | 152.8 kb | Distal (>10kb) Multiome | 866 | |
| chr19:48,964,515–48,966,446 | 154.2 kb | Distal (>10kb) Multiome | 1015 | |
| chr19:48,992,571–48,994,129 | 182.5 kb | Distal (>10kb) Multiome | 852 | |
| chr19:49,017,642–49,018,292 | 206.9 kb | Distal (>10kb) Multiome | 480 | |
| chr19:49,019,277–49,019,889 | 208.6 kb | Distal (>10kb) Multiome | 233 | |
| chr19:49,055,975–49,056,714 | 245.2 kb | Distal (>10kb) Multiome | 431 | |
| chr19:49,064,668–49,065,682 | 254.1 kb | Distal (>10kb) Multiome | 226 | |
| chr19:49,071,761–49,072,903 | 261.0 kb | Distal (>10kb) Multiome | 278 | |
| chr19:49,084,646–49,086,115 | 274.3 kb | Distal (>10kb) Multiome | 1030 |
Genomic view of the BCAT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.