This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for BAIAP2L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BAIAP2L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BAIAP2L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:98,106,660–98,107,619 | 294.2 kb | Distal (>10kb) Multiome | 870 | |
| chr7:98,251,470–98,252,647 | 148.9 kb | Distal (>10kb) Multiome | 846 | |
| chr7:98,280,710–98,282,616 | 119.6 kb | Distal (>10kb) Multiome HiCAR | 691 | |
| chr7:98,294,739–98,295,296 | 106.0 kb | Distal (>10kb) Multiome HiCAR | 363 | |
| chr7:98,305,831–98,306,470 | 94.9 kb | Distal (>10kb) Multiome HiCAR | 55 | |
| chr7:98,362,631–98,363,114 | 38.2 kb | Distal (>10kb) Multiome | 59 | |
| chr7:98,400,423–98,401,663 | 121 bp | At TSS Multiome | 752 | |
| chr7:98,470,267–98,471,178 | 69.7 kb | Distal (>10kb) Multiome | 246 | |
| chr7:98,616,379–98,618,423 | 216.2 kb | Distal (>10kb) Multiome | 357 |
Genomic view of the BAIAP2L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.