This gene encodes a member of the glycosyltransferase 31 family. The encoded protein synthesizes GalNAc:beta-1,3GlcNAc, a novel carbohydrate structure, on N- and O-glycans. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2013]
Transcription factors with Perturb-seq knockdown data for B3GALNT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = B3GALNT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of B3GALNT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:235,304,634–235,305,365 | 199.4 kb | Distal (>10kb) Multiome | 220 | |
| chr1:235,326,947–235,329,481 | 175.9 kb | Distal (>10kb) Multiome | 1010 | |
| chr1:235,367,126–235,367,788 | 137.0 kb | Distal (>10kb) Multiome | 851 | |
| chr1:235,501,260–235,501,461 | 3.0 kb | Proximal (<10kb) | 76 | |
| chr1:235,503,729–235,505,713 | 118 bp | At TSS Multiome | 1129 | |
| chr1:235,513,839–235,514,041 | 9.4 kb | Proximal (<10kb) | 168 | |
| chr1:235,546,455–235,547,226 | 42.3 kb | Distal (>10kb) Multiome | 80 | |
| chr1:235,642,093–235,643,505 | 138.8 kb | Distal (>10kb) Multiome | 410 | |
| chr1:235,648,967–235,650,841 | 145.7 kb | Distal (>10kb) Multiome | 689 |
Genomic view of the B3GALNT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.