Involved in regulation of gene expression. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ATXN7L3B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATXN7L3B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATXN7L3B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:74,408,179–74,409,302 | 129.0 kb | Distal (>10kb) Multiome | 185 | |
| chr12:74,537,322–74,538,432 | 25 bp | At TSS Multiome | 890 | |
| chr12:74,538,580–74,538,886 | 746 bp | At TSS | 128 | |
| chr12:74,539,305–74,540,076 | 1.5 kb | Proximal (<10kb) | 124 | |
| chr12:74,540,183–74,540,744 | 2.3 kb | Proximal (<10kb) | 47 | |
| chr12:74,541,189–74,541,399 | 3.4 kb | Proximal (<10kb) | 71 | |
| chr12:74,546,835–74,548,107 | 9.0 kb | Proximal (<10kb) | 71 |
Genomic view of the ATXN7L3B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.