ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. [provided by RefSeq, Jul 2021]
Transcription factors with Perturb-seq knockdown data for ARL4D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARL4D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARL4D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:43,124,981–43,125,702 | 273.5 kb | Distal (>10kb) Multiome | 837 | |
| chr17:43,169,744–43,171,576 | 227.9 kb | Distal (>10kb) Multiome | 1018 | |
| chr17:43,211,494–43,212,392 | 187.1 kb | Distal (>10kb) Multiome | 586 | |
| chr17:43,359,784–43,361,254 | 37.9 kb | Distal (>10kb) Multiome | 981 | |
| chr17:43,367,132–43,369,458 | 29.8 kb | Distal (>10kb) Multiome | 1146 | |
| chr17:43,388,101–43,389,658 | 9.6 kb | Proximal (<10kb) Multiome | 770 | |
| chr17:43,394,022–43,394,219 | 4.8 kb | Proximal (<10kb) | 449 | |
| chr17:43,396,093–43,396,353 | 2.6 kb | Proximal (<10kb) | 43 | |
| chr17:43,396,555–43,396,987 | 2.3 kb | Proximal (<10kb) Multiome | 27 | |
| chr17:43,398,359–43,400,469 | 81 bp | At TSS Multiome | 827 | |
| chr17:43,403,154–43,404,714 | 5.0 kb | Proximal (<10kb) Multiome | 252 | |
| chr17:43,406,748–43,407,604 | 8.2 kb | Proximal (<10kb) Multiome | 102 | |
| chr17:43,438,695–43,439,408 | 40.0 kb | Distal (>10kb) Multiome | 86 | |
| chr17:43,457,977–43,459,063 | 59.5 kb | Distal (>10kb) Multiome | 328 | |
| chr17:43,483,594–43,484,268 | 84.9 kb | Distal (>10kb) Multiome HiCAR | 1016 | |
| chr17:43,530,368–43,531,356 | 131.9 kb | Distal (>10kb) Multiome | 828 | |
| chr17:43,545,066–43,547,010 | 146.7 kb | Distal (>10kb) Multiome | 999 | |
| chr17:43,694,216–43,694,699 | 295.5 kb | Distal (>10kb) Multiome | 408 |
Genomic view of the ARL4D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.