The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for ARIH2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARIH2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARIH2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:48,634,696–48,636,251 | 283.3 kb | Distal (>10kb) Multiome | 898 | |
| chr3:48,655,787–48,657,257 | 262.4 kb | Distal (>10kb) Multiome | 438 | |
| chr3:48,661,275–48,664,636 | 257.1 kb | Distal (>10kb) Multiome | 1248 | |
| chr3:48,685,362–48,686,531 | 233.0 kb | Distal (>10kb) Multiome | 770 | |
| chr3:48,716,958–48,717,863 | 201.5 kb | Distal (>10kb) Multiome | 634 | |
| chr3:48,847,059–48,848,224 | 71.1 kb | Distal (>10kb) Multiome | 772 | |
| chr3:48,898,423–48,899,110 | 20.0 kb | Distal (>10kb) Multiome | 739 | |
| chr3:48,918,234–48,919,609 | 61 bp | At TSS Multiome | 877 | |
| chr3:48,989,537–48,991,069 | 71.2 kb | Distal (>10kb) Multiome | 552 | |
| chr3:49,003,975–49,004,995 | 85.6 kb | Distal (>10kb) Multiome | 209 | |
| chr3:49,006,738–49,008,496 | 89.0 kb | Distal (>10kb) Multiome | 955 | |
| chr3:49,017,789–49,018,870 | 99.6 kb | Distal (>10kb) Multiome | 780 | |
| chr3:49,020,066–49,022,597 | 102.9 kb | Distal (>10kb) Multiome | 1064 | |
| chr3:49,028,856–49,029,800 | 110.6 kb | Distal (>10kb) Multiome | 974 | |
| chr3:49,093,005–49,094,956 | 175.4 kb | Distal (>10kb) Multiome | 944 | |
| chr3:49,104,279–49,105,309 | 185.9 kb | Distal (>10kb) Multiome | 712 | |
| chr3:49,120,575–49,121,282 | 202.1 kb | Distal (>10kb) Multiome | 765 | |
| chr3:49,132,603–49,133,965 | 214.8 kb | Distal (>10kb) Multiome | 652 | |
| chr3:49,166,057–49,166,586 | 247.5 kb | Distal (>10kb) Multiome | 622 | |
| chr3:49,170,896–49,171,950 | 252.5 kb | Distal (>10kb) Multiome | 781 |
Genomic view of the ARIH2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.