Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]
Transcription factors with Perturb-seq knockdown data for ARHGEF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGEF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGEF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:155,688,087–155,689,328 | 289.7 kb | Distal (>10kb) Multiome | 838 | |
| chr1:155,745,339–155,745,870 | 232.9 kb | Distal (>10kb) Multiome | 505 | |
| chr1:155,806,537–155,807,073 | 171.7 kb | Distal (>10kb) Multiome | 15 | |
| chr1:155,856,932–155,857,529 | 121.3 kb | Distal (>10kb) Multiome | 639 | |
| chr1:155,859,095–155,860,745 | 119.1 kb | Distal (>10kb) Multiome | 632 | |
| chr1:155,910,686–155,911,579 | 67.2 kb | Distal (>10kb) Multiome | 691 | |
| chr1:155,934,107–155,934,787 | 44.1 kb | Distal (>10kb) Multiome | 872 | |
| chr1:155,975,984–155,976,440 | 2.1 kb | Proximal (<10kb) | 343 | |
| chr1:155,976,727–155,977,187 | 1.6 kb | Proximal (<10kb) Multiome | 316 | |
| chr1:155,977,296–155,979,264 | 173 bp | At TSS Multiome | 698 | |
| chr1:156,020,469–156,021,128 | 42.4 kb | Distal (>10kb) Multiome | 558 | |
| chr1:156,052,923–156,055,358 | 76.3 kb | Distal (>10kb) Multiome | 1053 | |
| chr1:156,060,806–156,061,738 | 82.7 kb | Distal (>10kb) Multiome | 318 | |
| chr1:156,063,507–156,064,184 | 85.3 kb | Distal (>10kb) Multiome | 199 | |
| chr1:156,076,488–156,077,355 | 98.5 kb | Distal (>10kb) Multiome | 246 | |
| chr1:156,081,942–156,083,586 | 104.1 kb | Distal (>10kb) Multiome | 670 | |
| chr1:156,105,879–156,107,316 | 128.0 kb | Distal (>10kb) Multiome | 663 | |
| chr1:156,114,184–156,115,669 | 136.1 kb | Distal (>10kb) Multiome | 824 | |
| chr1:156,123,520–156,124,091 | 145.3 kb | Distal (>10kb) Multiome | 679 | |
| chr1:156,129,945–156,130,610 | 151.9 kb | Distal (>10kb) Multiome | 733 | |
| chr1:156,146,058–156,146,760 | 167.8 kb | Distal (>10kb) Multiome | 429 | |
| chr1:156,149,593–156,150,242 | 171.5 kb | Distal (>10kb) Multiome | 194 | |
| chr1:156,160,602–156,161,218 | 182.5 kb | Distal (>10kb) Multiome | 218 | |
| chr1:156,181,487–156,182,119 | 203.2 kb | Distal (>10kb) Multiome | 145 | |
| chr1:156,184,002–156,185,155 | 205.9 kb | Distal (>10kb) Multiome | 216 | |
| chr1:156,193,531–156,194,375 | 215.4 kb | Distal (>10kb) Multiome | 751 | |
| chr1:156,212,611–156,213,686 | 234.6 kb | Distal (>10kb) Multiome | 893 | |
| chr1:156,245,413–156,246,269 | 267.2 kb | Distal (>10kb) Multiome | 380 |
Genomic view of the ARHGEF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.