Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression (Lv et al., 2007 [PubMed 17454002]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for ARHGAP19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGAP19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGAP19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:97,037,342–97,037,879 | 255.1 kb | Distal (>10kb) Multiome | 469 | |
| chr10:97,089,264–97,089,736 | 203.1 kb | Distal (>10kb) Multiome | 49 | |
| chr10:97,179,559–97,180,186 | 112.7 kb | Distal (>10kb) Multiome | 190 | |
| chr10:97,185,462–97,186,037 | 106.7 kb | Distal (>10kb) Multiome | 248 | |
| chr10:97,195,967–97,196,850 | 96.1 kb | Distal (>10kb) Multiome | 469 | |
| chr10:97,291,972–97,293,103 | 40 bp | At TSS Multiome | 945 | |
| chr10:97,318,840–97,320,386 | 26.5 kb | Distal (>10kb) Multiome | 836 | |
| chr10:97,333,472–97,335,742 | 42.3 kb | Distal (>10kb) Multiome | 917 | |
| chr10:97,336,929–97,337,706 | 44.7 kb | Distal (>10kb) Multiome | 362 | |
| chr10:97,400,817–97,401,691 | 108.7 kb | Distal (>10kb) Multiome | 644 | |
| chr10:97,407,246–97,407,739 | 114.8 kb | Distal (>10kb) Multiome | 539 | |
| chr10:97,418,830–97,419,461 | 126.5 kb | Distal (>10kb) Multiome | 323 | |
| chr10:97,425,050–97,426,796 | 133.5 kb | Distal (>10kb) Multiome | 715 | |
| chr10:97,445,521–97,446,585 | 153.5 kb | Distal (>10kb) Multiome | 802 | |
| chr10:97,497,718–97,499,773 | 206.1 kb | Distal (>10kb) Multiome | 967 | |
| chr10:97,553,598–97,554,047 | 261.1 kb | Distal (>10kb) Multiome | 340 |
Genomic view of the ARHGAP19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.