AREL1
apoptosis resistant E3 ubiquitin protein ligase 1 | FIEL1, KIAA0317

Enables ubiquitin protein ligase activity. Involved in negative regulation of apoptotic process; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-2 DE-2.25
Biological processes 20 terms
cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)negative regulation of apoptotic process (GO:0043066)negative regulation of apoptotic process (GO:0043066)protein K11-linked ubiquitination (GO:0070979)protein K33-linked ubiquitination (GO:1990390)protein binding (GO:0005515)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)regulation of inflammatory response (GO:0050727)regulation of inflammatory response (GO:0050727)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-protein transferase activity (GO:0004842)ubiquitin-protein transferase activity (GO:0004842)
Expression (TPM)
AREL1 — as a Regulated Gene

TFs regulating AREL1 0 TFs

Transcription factors with Perturb-seq knockdown data for AREL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AREL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to AREL1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AREL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr14:74,417,196–74,418,934 295.1 kb Distal (>10kb) Multiome 153
chr14:74,425,677–74,426,474 287.0 kb Distal (>10kb) Multiome 342
chr14:74,442,382–74,443,260 270.4 kb Distal (>10kb) Multiome 53
chr14:74,470,530–74,471,370 242.2 kb Distal (>10kb) Multiome 31
chr14:74,492,838–74,494,443 219.5 kb Distal (>10kb) Multiome 820
chr14:74,500,815–74,501,591 211.9 kb Distal (>10kb) Multiome 179
chr14:74,611,325–74,612,912 100.4 kb Distal (>10kb) Multiome 552
chr14:74,620,601–74,621,179 92.2 kb Distal (>10kb) Multiome 257
chr14:74,763,078–74,763,795 50.2 kb Distal (>10kb) Multiome 808
chr14:74,879,596–74,880,720 167.0 kb Distal (>10kb) Multiome 108
chr14:74,881,522–74,882,475 168.8 kb Distal (>10kb) Multiome 877
chr14:74,922,804–74,923,467 210.2 kb Distal (>10kb) Multiome 458
chr14:74,955,358–74,956,099 242.6 kb Distal (>10kb) Multiome 457
chr14:74,980,538–74,981,185 267.8 kb Distal (>10kb) Multiome 205
chr14:75,002,395–75,003,398 289.7 kb Distal (>10kb) Multiome 767

Genome Browser

Genomic view of the AREL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr14:74,407,196 – 75,013,398
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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