This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for APOC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APOC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APOC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:44,643,571–44,644,620 | 270.4 kb | Distal (>10kb) Multiome | 710 | |
| chr19:44,747,085–44,747,789 | 166.8 kb | Distal (>10kb) Multiome | 653 | |
| chr19:44,757,112–44,758,480 | 156.9 kb | Distal (>10kb) Multiome | 209 | |
| chr19:44,758,633–44,759,104 | 155.4 kb | Distal (>10kb) Multiome | 80 | |
| chr19:44,770,589–44,771,108 | 143.6 kb | Distal (>10kb) Multiome | 367 | |
| chr19:44,777,671–44,778,314 | 136.4 kb | Distal (>10kb) Multiome | 353 | |
| chr19:44,800,231–44,800,829 | 113.7 kb | Distal (>10kb) Multiome | 508 | |
| chr19:44,807,965–44,809,338 | 106.2 kb | Distal (>10kb) Multiome | 652 | |
| chr19:44,844,448–44,848,668 | 69.5 kb | Distal (>10kb) Multiome | 1047 | |
| chr19:44,890,209–44,891,796 | 23.4 kb | Distal (>10kb) Multiome | 952 | |
| chr19:44,903,686–44,904,241 | 10.5 kb | Distal (>10kb) Multiome | 666 | |
| chr19:44,905,114–44,907,037 | 7.6 kb | Proximal (<10kb) Multiome | 645 | |
| chr19:44,909,850–44,910,571 | 3.8 kb | Proximal (<10kb) | 146 | |
| chr19:44,911,026–44,911,489 | 2.8 kb | Proximal (<10kb) | 533 | |
| chr19:44,913,546–44,915,671 | 839 bp | At TSS Multiome | 587 | |
| chr19:44,926,693–44,927,388 | 12.9 kb | Distal (>10kb) Multiome | 277 | |
| chr19:44,954,641–44,955,824 | 40.9 kb | Distal (>10kb) Multiome HiCAR | 835 | |
| chr19:45,001,031–45,002,639 | 87.1 kb | Distal (>10kb) Multiome | 694 | |
| chr19:45,038,879–45,039,566 | 124.8 kb | Distal (>10kb) Multiome HiCAR | 800 | |
| chr19:45,075,125–45,076,814 | 162.2 kb | Distal (>10kb) Multiome | 710 | |
| chr19:45,078,897–45,080,647 | 165.8 kb | Distal (>10kb) Multiome | 1012 | |
| chr19:45,091,042–45,093,574 | 178.7 kb | Distal (>10kb) Multiome | 959 | |
| chr19:45,177,803–45,179,711 | 264.2 kb | Distal (>10kb) Multiome | 899 |
Genomic view of the APOC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.