The protein encoded by this gene is a subunit of the AP-2 adaptor protein complex, which is involved in linking lipid and protein membrane components with the clathrin lattice. This interaction supports the formation of clathrin-coated vesicles, and the encoded subunit aids in the process by binding polyphosphoinositide-containing lipids in the cell membrane. [provided by RefSeq, Nov 2016]
Transcription factors with Perturb-seq knockdown data for AP2A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AP2A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AP2A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:636,786–637,700 | 288.8 kb | Distal (>10kb) Multiome | 161 | |
| chr11:693,835–696,330 | 230.5 kb | Distal (>10kb) Multiome | 873 | |
| chr11:705,737–706,270 | 219.8 kb | Distal (>10kb) Multiome | 361 | |
| chr11:720,619–721,074 | 205.0 kb | Distal (>10kb) Multiome | 156 | |
| chr11:727,901–728,499 | 197.7 kb | Distal (>10kb) Multiome | 686 | |
| chr11:746,704–748,069 | 178.6 kb | Distal (>10kb) Multiome | 755 | |
| chr11:762,582–763,602 | 162.6 kb | Distal (>10kb) Multiome | 326 | |
| chr11:776,216–778,328 | 148.5 kb | Distal (>10kb) Multiome | 770 | |
| chr11:783,385–783,909 | 142.2 kb | Distal (>10kb) Multiome | 278 | |
| chr11:797,112–798,675 | 127.6 kb | Distal (>10kb) Multiome | 697 | |
| chr11:804,241–805,812 | 120.6 kb | Distal (>10kb) Multiome | 725 | |
| chr11:808,894–810,402 | 116.2 kb | Distal (>10kb) Multiome | 976 | |
| chr11:818,369–820,592 | 106.3 kb | Distal (>10kb) Multiome | 749 | |
| chr11:826,980–828,116 | 98.4 kb | Distal (>10kb) Multiome | 662 | |
| chr11:828,933–831,262 | 95.5 kb | Distal (>10kb) Multiome | 491 | |
| chr11:832,323–833,565 | 93.0 kb | Distal (>10kb) Multiome | 562 | |
| chr11:842,034–843,556 | 83.2 kb | Distal (>10kb) Multiome | 794 | |
| chr11:843,773–845,220 | 81.4 kb | Distal (>10kb) Multiome | 664 | |
| chr11:849,082–850,270 | 76.1 kb | Distal (>10kb) Multiome | 229 | |
| chr11:910,337–911,591 | 14.9 kb | Distal (>10kb) Multiome | 754 | |
| chr11:925,038–926,264 | 40 bp | At TSS Multiome | 689 |
Genomic view of the AP2A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.