Enables histone binding activity; histone chaperone activity; and protein folding chaperone. Predicted to be involved in regulation of apoptotic process. Located in nucleus. Part of Swr1 complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ANP32E. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANP32E upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANP32E, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:150,010,143–150,011,088 | 225.4 kb | Distal (>10kb) Multiome | 961 | |
| chr1:150,066,903–150,067,886 | 168.5 kb | Distal (>10kb) Multiome | 986 | |
| chr1:150,149,493–150,150,439 | 86.0 kb | Distal (>10kb) Multiome | 448 | |
| chr1:150,162,838–150,163,636 | 72.8 kb | Distal (>10kb) Multiome | 550 | |
| chr1:150,213,532–150,214,095 | 22.4 kb | Distal (>10kb) Multiome | 441 | |
| chr1:150,234,435–150,235,519 | 1.4 kb | Proximal (<10kb) Multiome | 725 | |
| chr1:150,235,635–150,236,696 | 115 bp | At TSS Multiome | 905 | |
| chr1:150,255,443–150,256,199 | 19.6 kb | Distal (>10kb) Multiome | 441 | |
| chr1:150,256,563–150,257,324 | 20.9 kb | Distal (>10kb) Multiome | 223 | |
| chr1:150,257,589–150,258,594 | 22.0 kb | Distal (>10kb) Multiome | 233 | |
| chr1:150,259,728–150,260,778 | 24.0 kb | Distal (>10kb) Multiome | 362 | |
| chr1:150,268,574–150,269,453 | 33.0 kb | Distal (>10kb) Multiome | 785 | |
| chr1:150,281,629–150,283,038 | 46.3 kb | Distal (>10kb) Multiome | 503 | |
| chr1:150,293,680–150,294,144 | 57.7 kb | Distal (>10kb) Multiome | 755 | |
| chr1:150,313,761–150,314,506 | 78.0 kb | Distal (>10kb) Multiome | 108 | |
| chr1:150,321,137–150,321,825 | 85.4 kb | Distal (>10kb) Multiome | 806 | |
| chr1:150,363,368–150,364,980 | 127.9 kb | Distal (>10kb) Multiome | 971 | |
| chr1:150,487,154–150,487,710 | 251.2 kb | Distal (>10kb) Multiome | 929 | |
| chr1:150,515,085–150,516,227 | 279.6 kb | Distal (>10kb) Multiome | 781 |
Genomic view of the ANP32E locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.