A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Transcription factors with Perturb-seq knockdown data for ANAPC4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANAPC4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANAPC4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:25,081,936–25,082,684 | 294.9 kb | Distal (>10kb) Multiome | 92 | |
| chr4:25,131,511–25,132,461 | 245.2 kb | Distal (>10kb) Multiome | 74 | |
| chr4:25,159,654–25,161,108 | 216.8 kb | Distal (>10kb) Multiome HiCAR | 899 | |
| chr4:25,233,604–25,234,892 | 143.3 kb | Distal (>10kb) Multiome | 812 | |
| chr4:25,312,481–25,313,179 | 64.5 kb | Distal (>10kb) Multiome | 951 | |
| chr4:25,368,152–25,368,608 | 8.7 kb | Proximal (<10kb) | 68 | |
| chr4:25,370,350–25,370,927 | 6.3 kb | Proximal (<10kb) | 24 | |
| chr4:25,376,361–25,378,027 | 116 bp | At TSS Multiome | 760 | |
| chr4:25,585,669–25,586,415 | 208.8 kb | Distal (>10kb) Multiome | 122 | |
| chr4:25,654,656–25,656,013 | 278.2 kb | Distal (>10kb) Multiome | 352 |
Genomic view of the ANAPC4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.