This gene is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Feb 2013]
Transcription factors with Perturb-seq knockdown data for AGFG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AGFG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AGFG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:100,266,531–100,267,045 | 272.4 kb | Distal (>10kb) Multiome | 24 | |
| chr7:100,270,225–100,270,813 | 268.6 kb | Distal (>10kb) Multiome | 103 | |
| chr7:100,271,732–100,272,774 | 266.9 kb | Distal (>10kb) Multiome | 530 | |
| chr7:100,335,652–100,336,470 | 203.1 kb | Distal (>10kb) Multiome | 706 | |
| chr7:100,381,682–100,382,670 | 157.1 kb | Distal (>10kb) Multiome | 49 | |
| chr7:100,428,059–100,431,175 | 110.2 kb | Distal (>10kb) Multiome | 1296 | |
| chr7:100,435,379–100,436,927 | 102.7 kb | Distal (>10kb) Multiome | 931 | |
| chr7:100,450,379–100,450,973 | 88.5 kb | Distal (>10kb) Multiome | 785 | |
| chr7:100,478,582–100,479,753 | 59.8 kb | Distal (>10kb) Multiome | 842 | |
| chr7:100,482,937–100,484,533 | 55.5 kb | Distal (>10kb) Multiome | 677 | |
| chr7:100,538,557–100,539,759 | 165 bp | At TSS Multiome | 858 | |
| chr7:100,542,221–100,542,986 | 3.5 kb | Proximal (<10kb) Multiome | 274 | |
| chr7:100,544,726–100,545,091 | 5.5 kb | Proximal (<10kb) | 185 | |
| chr7:100,569,177–100,570,642 | 30.4 kb | Distal (>10kb) Multiome | 855 | |
| chr7:100,585,161–100,587,241 | 47.2 kb | Distal (>10kb) Multiome | 966 | |
| chr7:100,611,685–100,612,981 | 73.0 kb | Distal (>10kb) Multiome | 767 | |
| chr7:100,626,427–100,627,057 | 87.6 kb | Distal (>10kb) Multiome | 415 | |
| chr7:100,656,111–100,656,626 | 117.2 kb | Distal (>10kb) Multiome | 653 | |
| chr7:100,673,043–100,674,892 | 134.3 kb | Distal (>10kb) Multiome | 934 | |
| chr7:100,674,996–100,676,406 | 136.7 kb | Distal (>10kb) Multiome | 439 | |
| chr7:100,691,570–100,692,163 | 152.7 kb | Distal (>10kb) Multiome | 364 | |
| chr7:100,693,475–100,694,667 | 155.1 kb | Distal (>10kb) Multiome | 607 | |
| chr7:100,705,140–100,706,426 | 166.7 kb | Distal (>10kb) Multiome | 962 | |
| chr7:100,827,001–100,828,324 | 288.5 kb | Distal (>10kb) Multiome | 794 | |
| chr7:100,835,906–100,837,766 | 297.6 kb | Distal (>10kb) Multiome | 766 |
Genomic view of the AGFG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.