Enables clathrin binding activity. Predicted to be involved in intracellular transport. Located in Golgi apparatus; cytosol; and nucleoplasm. Part of AP-1 adaptor complex. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for AFTPH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AFTPH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AFTPH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:64,227,941–64,228,667 | 296.0 kb | Distal (>10kb) Multiome | 493 | |
| chr2:64,251,480–64,252,200 | 272.7 kb | Distal (>10kb) Multiome | 104 | |
| chr2:64,252,396–64,252,854 | 271.6 kb | Distal (>10kb) Multiome | 93 | |
| chr2:64,276,376–64,277,307 | 247.6 kb | Distal (>10kb) Multiome | 252 | |
| chr2:64,330,958–64,331,642 | 193.1 kb | Distal (>10kb) Multiome | 275 | |
| chr2:64,404,071–64,404,983 | 120.0 kb | Distal (>10kb) Multiome | 340 | |
| chr2:64,453,131–64,455,109 | 70.1 kb | Distal (>10kb) Multiome | 767 | |
| chr2:64,459,486–64,459,967 | 64.7 kb | Distal (>10kb) Multiome | 89 | |
| chr2:64,523,863–64,525,127 | 65 bp | At TSS Multiome | 964 | |
| chr2:64,608,995–64,609,973 | 85.1 kb | Distal (>10kb) Multiome | 430 | |
| chr2:64,622,422–64,623,223 | 98.3 kb | Distal (>10kb) Multiome | 152 | |
| chr2:64,644,172–64,645,396 | 120.8 kb | Distal (>10kb) Multiome | 716 | |
| chr2:64,653,208–64,654,885 | 129.6 kb | Distal (>10kb) Multiome | 978 | |
| chr2:64,727,848–64,728,433 | 203.7 kb | Distal (>10kb) Multiome | 278 | |
| chr2:64,750,029–64,752,111 | 226.8 kb | Distal (>10kb) Multiome | 1065 | |
| chr2:64,767,781–64,768,499 | 243.8 kb | Distal (>10kb) Multiome | 733 |
Genomic view of the AFTPH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.