AEBP1

AE binding protein 1 | ACLP

This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013]

Member of: DE-9 Developmental clusters: GC6

Biological processes 24 terms

DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)collagen binding (GO:0005518)cytoplasm (GO:0005737)extracellular exosome (GO:0070062)extracellular matrix (GO:0031012)extracellular matrix (GO:0031012)extracellular matrix structural constituent (GO:0005201)extracellular region (GO:0005576)extracellular region (GO:0005576)metallocarboxypeptidase activity (GO:0004181)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleus (GO:0005634)peptide metabolic process (GO:0006518)protein processing (GO:0016485)proteolysis (GO:0006508)regulation of DNA-templated transcription (GO:0006355)regulation of DNA-templated transcription (GO:0006355)regulation of collagen fibril organization (GO:1904026)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating AEBP1 0 TFs

Transcription factors with Perturb-seq knockdown data for AEBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AEBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to AEBP1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AEBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:43,838,582–43,839,204	265.3 kb	Distal (>10kb) Multiome	647
chr7:43,868,905–43,870,110	234.9 kb	Distal (>10kb) Multiome	804
chr7:43,905,962–43,907,078	197.7 kb	Distal (>10kb) Multiome	557
chr7:43,926,113–43,927,072	177.8 kb	Distal (>10kb) Multiome	1004
chr7:43,985,975–43,986,501	118.0 kb	Distal (>10kb) Multiome	113
chr7:44,018,938–44,019,667	85.1 kb	Distal (>10kb) Multiome	564
chr7:44,038,952–44,039,494	65.2 kb	Distal (>10kb) Multiome	215
chr7:44,044,335–44,045,323	59.6 kb	Distal (>10kb) Multiome	832
chr7:44,063,611–44,064,251	40.3 kb	Distal (>10kb) Multiome	121
chr7:44,065,163–44,066,086	38.5 kb	Distal (>10kb) Multiome	198
chr7:44,081,995–44,083,183	21.7 kb	Distal (>10kb) Multiome	909
chr7:44,103,745–44,105,419	57 bp	At TSS Multiome	267
chr7:44,112,627–44,113,466	8.7 kb	Proximal (<10kb) Multiome HiCAR	237
chr7:44,123,183–44,124,199	19.3 kb	Distal (>10kb) Multiome	814
chr7:44,145,408–44,146,956	41.9 kb	Distal (>10kb) Multiome	347
chr7:44,200,748–44,201,465	96.6 kb	Distal (>10kb) Multiome	738
chr7:44,218,223–44,218,706	114.1 kb	Distal (>10kb) Multiome	215
chr7:44,275,748–44,276,529	171.9 kb	Distal (>10kb) Multiome	146
chr7:44,309,084–44,310,124	205.5 kb	Distal (>10kb) Multiome	263
chr7:44,325,052–44,325,687	221.1 kb	Distal (>10kb) Multiome	118

Genome Browser

Genomic view of the AEBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.