Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ADRA2C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADRA2C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADRA2C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:3,480,590–3,481,619 | 285.4 kb | Distal (>10kb) Multiome | 364 | |
| chr4:3,531,831–3,533,168 | 233.8 kb | Distal (>10kb) Multiome | 740 | |
| chr4:3,765,307–3,767,869 | 1.2 kb | Proximal (<10kb) Multiome | 485 | |
| chr4:3,807,895–3,808,372 | 41.7 kb | Distal (>10kb) Multiome | 54 | |
| chr4:3,847,183–3,847,841 | 81.0 kb | Distal (>10kb) Multiome | 31 | |
| chr4:3,862,359–3,863,269 | 96.4 kb | Distal (>10kb) Multiome HiCAR | 188 | |
| chr4:3,871,162–3,872,292 | 105.3 kb | Distal (>10kb) Multiome HiCAR | 206 | |
| chr4:3,880,124–3,880,883 | 114.3 kb | Distal (>10kb) Multiome HiCAR | 317 | |
| chr4:3,925,756–3,926,526 | 159.9 kb | Distal (>10kb) Multiome | 7 | |
| chr4:3,927,408–3,928,004 | 161.3 kb | Distal (>10kb) Multiome | 19 | |
| chr4:3,954,698–3,956,574 | 189.5 kb | Distal (>10kb) Multiome | 434 | |
| chr4:4,048,067–4,048,621 | 282.0 kb | Distal (>10kb) Multiome | 77 |
Genomic view of the ADRA2C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.