This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for ADGRL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADGRL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADGRL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:81,306,031–81,306,456 | at TSS | At TSS | 186 | |
| chr1:81,312,252–81,312,811 | 6.1 kb | Proximal (<10kb) | 115 | |
| chr1:81,313,233–81,313,577 | 7.0 kb | Proximal (<10kb) | 31 | |
| chr1:81,662,755–81,663,751 | 137.2 kb | Distal (>10kb) Multiome | 117 | |
| chr1:81,799,927–81,803,800 | 2.8 kb | Proximal (<10kb) Multiome | 772 | |
| chr1:81,804,290–81,804,550 | 3.9 kb | Proximal (<10kb) | 95 | |
| chr1:81,848,463–81,849,577 | 48.7 kb | Distal (>10kb) Multiome | 306 | |
| chr1:81,920,155–81,920,752 | 120.2 kb | Distal (>10kb) Multiome | 269 | |
| chr1:83,548,037–83,548,981 | 1748.1 kb | Distal (>10kb) Multiome HiCAR | 148 |
Genomic view of the ADGRL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.