This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for ADCY5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADCY5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADCY5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:123,169,519–123,169,980 | 278.8 kb | Distal (>10kb) Multiome | 64 | |
| chr3:123,201,446–123,202,796 | 246.7 kb | Distal (>10kb) Multiome | 651 | |
| chr3:123,314,223–123,315,571 | 133.5 kb | Distal (>10kb) Multiome | 264 | |
| chr3:123,447,574–123,450,476 | 446 bp | At TSS Multiome | 427 | |
| chr3:123,457,914–123,458,148 | 8.8 kb | Proximal (<10kb) | 45 | |
| chr3:123,571,319–123,571,775 | 123.0 kb | Distal (>10kb) Multiome | 101 | |
| chr3:123,584,314–123,585,841 | 136.6 kb | Distal (>10kb) Multiome | 988 | |
| chr3:123,600,718–123,601,402 | 152.5 kb | Distal (>10kb) Multiome | 74 | |
| chr3:123,636,347–123,636,942 | 188.2 kb | Distal (>10kb) Multiome | 211 |
Genomic view of the ADCY5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.