This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for ADAR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:154,328,267–154,328,890 | 299.3 kb | Distal (>10kb) Multiome | 261 | |
| chr1:154,352,626–154,353,487 | 274.7 kb | Distal (>10kb) Multiome | 466 | |
| chr1:154,404,987–154,406,067 | 222.5 kb | Distal (>10kb) Multiome | 731 | |
| chr1:154,489,011–154,489,730 | 138.5 kb | Distal (>10kb) Multiome | 82 | |
| chr1:154,493,110–154,493,579 | 134.6 kb | Distal (>10kb) Multiome | 134 | |
| chr1:154,501,716–154,502,717 | 125.3 kb | Distal (>10kb) Multiome | 212 | |
| chr1:154,558,123–154,559,826 | 69.1 kb | Distal (>10kb) Multiome | 1173 | |
| chr1:154,567,476–154,568,396 | 60.0 kb | Distal (>10kb) Multiome | 774 | |
| chr1:154,607,914–154,609,125 | 19.2 kb | Distal (>10kb) Multiome | 720 | |
| chr1:154,627,216–154,628,267 | 104 bp | At TSS Multiome | 850 | |
| chr1:154,683,607–154,684,346 | 56.1 kb | Distal (>10kb) Multiome | 39 | |
| chr1:154,760,465–154,760,941 | 132.7 kb | Distal (>10kb) Multiome | 418 | |
| chr1:154,813,354–154,814,052 | 185.7 kb | Distal (>10kb) Multiome | 189 | |
| chr1:154,870,031–154,870,680 | 242.4 kb | Distal (>10kb) Multiome | 300 |
Genomic view of the ADAR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.