Enables medium-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty acid metabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ACSF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACSF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACSF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:50,150,777–50,152,506 | 275.1 kb | Distal (>10kb) Multiome | 900 | |
| chr17:50,161,052–50,162,135 | 264.5 kb | Distal (>10kb) Multiome | 691 | |
| chr17:50,177,880–50,178,665 | 247.8 kb | Distal (>10kb) Multiome | 675 | |
| chr17:50,199,586–50,201,292 | 225.6 kb | Distal (>10kb) Multiome | 798 | |
| chr17:50,273,066–50,273,646 | 152.9 kb | Distal (>10kb) Multiome | 411 | |
| chr17:50,274,084–50,274,945 | 151.6 kb | Distal (>10kb) Multiome | 242 | |
| chr17:50,310,314–50,311,981 | 114.5 kb | Distal (>10kb) Multiome | 314 | |
| chr17:50,312,127–50,312,775 | 113.5 kb | Distal (>10kb) Multiome | 37 | |
| chr17:50,345,523–50,346,998 | 80.0 kb | Distal (>10kb) Multiome | 809 | |
| chr17:50,363,392–50,364,195 | 62.3 kb | Distal (>10kb) Multiome | 164 | |
| chr17:50,372,860–50,373,487 | 53.0 kb | Distal (>10kb) Multiome | 999 | |
| chr17:50,397,227–50,397,885 | 28.6 kb | Distal (>10kb) Multiome | 1045 | |
| chr17:50,425,595–50,426,626 | 64 bp | At TSS Multiome | 619 | |
| chr17:50,478,411–50,479,262 | 52.7 kb | Distal (>10kb) Multiome | 956 | |
| chr17:50,508,047–50,508,856 | 82.3 kb | Distal (>10kb) Multiome | 332 | |
| chr17:50,541,672–50,542,697 | 116.0 kb | Distal (>10kb) Multiome | 772 | |
| chr17:50,546,778–50,547,615 | 121.0 kb | Distal (>10kb) Multiome | 786 | |
| chr17:50,558,590–50,561,781 | 134.4 kb | Distal (>10kb) Multiome | 587 | |
| chr17:50,586,525–50,587,142 | 160.6 kb | Distal (>10kb) Multiome | 43 | |
| chr17:50,634,652–50,635,325 | 208.9 kb | Distal (>10kb) Multiome | 471 | |
| chr17:50,707,179–50,708,006 | 281.5 kb | Distal (>10kb) Multiome | 1055 | |
| chr17:50,719,167–50,720,018 | 293.4 kb | Distal (>10kb) Multiome | 1050 |
Genomic view of the ACSF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.