The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in several protein-coding and non-protein-coding variants. [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for ABCD4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABCD4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABCD4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:74,018,639–74,019,694 | 283.7 kb | Distal (>10kb) Multiome | 791 | |
| chr14:74,083,828–74,085,467 | 218.3 kb | Distal (>10kb) Multiome | 824 | |
| chr14:74,257,088–74,257,807 | 45.3 kb | Distal (>10kb) Multiome | 415 | |
| chr14:74,294,346–74,294,562 | 8.4 kb | Proximal (<10kb) | 93 | |
| chr14:74,298,976–74,299,273 | 3.7 kb | Proximal (<10kb) | 110 | |
| chr14:74,302,423–74,303,735 | 105 bp | At TSS Multiome | 863 | |
| chr14:74,326,054–74,327,644 | 23.9 kb | Distal (>10kb) Multiome | 320 | |
| chr14:74,347,561–74,349,516 | 45.7 kb | Distal (>10kb) Multiome | 231 | |
| chr14:74,362,136–74,363,080 | 59.6 kb | Distal (>10kb) Multiome | 318 | |
| chr14:74,392,794–74,393,544 | 90.3 kb | Distal (>10kb) Multiome | 159 | |
| chr14:74,417,196–74,418,934 | 115.0 kb | Distal (>10kb) Multiome | 153 | |
| chr14:74,425,677–74,426,474 | 123.1 kb | Distal (>10kb) Multiome | 342 | |
| chr14:74,442,382–74,443,260 | 139.7 kb | Distal (>10kb) Multiome | 53 | |
| chr14:74,470,530–74,471,370 | 167.9 kb | Distal (>10kb) Multiome HiCAR | 31 | |
| chr14:74,492,838–74,494,443 | 190.6 kb | Distal (>10kb) Multiome | 820 | |
| chr14:74,500,815–74,501,591 | 198.2 kb | Distal (>10kb) Multiome HiCAR | 179 |
Genomic view of the ABCD4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.