Predicted to enable transcription coactivator activity. Acts upstream of or within negative regulation of cell growth. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SERTAD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SERTAD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SERTAD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:64,404,071–64,404,983 | 249.5 kb | Distal (>10kb) Multiome | 340 | |
| chr2:64,453,131–64,455,109 | 199.6 kb | Distal (>10kb) Multiome | 767 | |
| chr2:64,459,486–64,459,967 | 194.3 kb | Distal (>10kb) Multiome | 89 | |
| chr2:64,523,863–64,525,127 | 129.6 kb | Distal (>10kb) Multiome | 964 | |
| chr2:64,608,995–64,609,973 | 44.5 kb | Distal (>10kb) Multiome | 430 | |
| chr2:64,622,422–64,623,223 | 31.2 kb | Distal (>10kb) Multiome HiCAR | 152 | |
| chr2:64,644,172–64,645,396 | 8.7 kb | Proximal (<10kb) Multiome HiCAR | 716 | |
| chr2:64,646,399–64,646,623 | 7.3 kb | Proximal (<10kb) | 325 | |
| chr2:64,653,208–64,654,885 | 68 bp | At TSS Multiome | 978 | |
| chr2:64,727,848–64,728,433 | 74.2 kb | Distal (>10kb) Multiome | 278 | |
| chr2:64,750,029–64,752,111 | 97.3 kb | Distal (>10kb) Multiome | 1065 | |
| chr2:64,767,781–64,768,499 | 114.2 kb | Distal (>10kb) Multiome HiCAR | 733 | |
| chr2:64,859,294–64,860,146 | 205.9 kb | Distal (>10kb) Multiome | 654 | |
| chr2:64,864,705–64,865,856 | 211.7 kb | Distal (>10kb) Multiome HiCAR | 538 |
Genomic view of the SERTAD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.