This 10-gene module includes F2R, TMPRSS2, SOX11, ATP1A1, and KIF21A, with top enriched terms related to protease-activated receptor signaling, serine protease activity, and ion transport. Knockdown of GATA4 activates this module, while knockdown of SOX17, FOXA2, and EOMESODERMIN repress it. The module's enrichment in protease signaling and ion homeostasis suggests a role in early endoderm specification with potential involvement in cell-cell communication pathways.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.