The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Transcription factors with Perturb-seq knockdown data for ATP1A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP1A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP1A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:116,138,890–116,139,376 | 234.1 kb | Distal (>10kb) Multiome HiCAR | 625 | |
| chr1:116,151,870–116,152,550 | 221.1 kb | Distal (>10kb) Multiome HiCAR | 538 | |
| chr1:116,167,654–116,168,661 | 204.8 kb | Distal (>10kb) Multiome | 379 | |
| chr1:116,372,503–116,374,831 | 64 bp | At TSS Multiome | 903 | |
| chr1:116,376,243–116,376,555 | 3.0 kb | Proximal (<10kb) | 266 | |
| chr1:116,415,510–116,416,727 | 42.8 kb | Distal (>10kb) Multiome | 525 | |
| chr1:116,418,287–116,418,947 | 45.3 kb | Distal (>10kb) Multiome | 835 | |
| chr1:116,420,956–116,421,526 | 47.8 kb | Distal (>10kb) Multiome | 81 | |
| chr1:116,485,040–116,485,738 | 112.1 kb | Distal (>10kb) Multiome HiCAR | 519 | |
| chr1:116,569,966–116,571,655 | 197.7 kb | Distal (>10kb) Multiome | 829 | |
| chr1:116,666,816–116,668,150 | 294.4 kb | Distal (>10kb) Multiome | 530 |
Genomic view of the ATP1A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.