Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Transcription factors with Perturb-seq knockdown data for F2R. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = F2R upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of F2R, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:76,504,460–76,505,155 | 211.3 kb | Distal (>10kb) Multiome | 40 | |
| chr5:76,548,249–76,549,423 | 167.4 kb | Distal (>10kb) Multiome | 149 | |
| chr5:76,715,026–76,716,740 | 54 bp | At TSS Multiome | 666 | |
| chr5:76,716,876–76,717,040 | 751 bp | At TSS | 180 | |
| chr5:76,789,270–76,790,249 | 73.8 kb | Distal (>10kb) Multiome | 123 | |
| chr5:76,808,093–76,808,802 | 92.3 kb | Distal (>10kb) Multiome | 237 | |
| chr5:76,818,476–76,819,940 | 102.8 kb | Distal (>10kb) Multiome | 686 | |
| chr5:76,873,943–76,874,791 | 158.3 kb | Distal (>10kb) Multiome | 261 | |
| chr5:76,953,306–76,954,445 | 237.6 kb | Distal (>10kb) Multiome | 235 |
Genomic view of the F2R locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.