This gene is located upstream of XIST, within the X-inactivation center (XIC). It produces a spliced long non-coding RNA that is thought to positively regulate the expression of XIST, which is essential for the initiation and spread of X-inactivation. [provided by RefSeq, May 2015]
Transcription factors with Perturb-seq knockdown data for FTX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FTX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FTX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:74,249,927–74,250,404 | 43.4 kb | Distal (>10kb) Multiome | 183 | |
| chrX:74,259,954–74,260,568 | 33.4 kb | Distal (>10kb) Multiome | 106 | |
| chrX:74,290,612–74,290,985 | 1.4 kb | Proximal (<10kb) | 148 | |
| chrX:74,292,249–74,293,905 | 1.0 kb | Proximal (<10kb) Multiome | 594 | |
| chrX:74,325,234–74,326,322 | 32.1 kb | Distal (>10kb) Multiome | 229 | |
| chrX:74,419,854–74,421,997 | 126.9 kb | Distal (>10kb) Multiome | 370 | |
| chrX:74,422,455–74,423,310 | 129.4 kb | Distal (>10kb) Multiome | 202 | |
| chrX:74,535,197–74,537,347 | 243.1 kb | Distal (>10kb) Multiome | 425 |
Genomic view of the FTX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.