DE-3 ›

DE-3.24

Submodule 15 genes

MAPK signaling and chromatin regulation pathway

This module contains 15 genes including BRAF, SOS1, TNKS, EHMT1, and COP1, with top enriched terms indicating involvement in MAPK signaling cascade, protein ubiquitination, and histone methylation. Knockdown of FOXA2 activates this module, while knockdown of SOX17 represses it.

Key terms: RNA metabolic process regulation of macromolecule metabolic process regulation of DNA-templated transcription regulation of biosynthetic process Notable genes: BRAF SOS1 TNKS EHMT1 COP1 ZNF148 RBFOX2 ASH1L

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (15)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

| |
Low
High z
Huangfu Lab · Publications · Resources · Contact