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DE-3.16

Submodule 17 genes

Negative regulation of developmental processes

This module contains 17 genes including GATA3, TET1, SORL1, COL18A1, and GAD1, enriched for negative regulation of developmental processes. Knockdown of SETDB1 and KLF8 represses this module, suggesting these factors normally support its expression during ESC-to-DE differentiation.

Key terms: negative regulation of developmental process cellular response to granulocyte macrophage colony-stimulating factor stimulus response to granulocyte macrophage colony-stimulating factor response to endogenous stimulus Notable genes: GATA3 TET1 SORL1 COL18A1 GAD1 TBX3 SGCE COL9A2 Top TFs: SETDB1 KLF8

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (16)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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