SORL1

SORL1

sortilin related receptor 1 | LR11, LRP9, SorLA, SorLA-1, gp250, C11orf32

This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease. [provided by RefSeq, Feb 2016]

Member of: DE-3 DE-3.16 Developmental clusters: GC4

Biological processes 105 terms

Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)Golgi cisterna (GO:0031985)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)adaptive thermogenesis (GO:1990845)adaptive thermogenesis (GO:1990845)amyloid-beta binding (GO:0001540)amyloid-beta binding (GO:0001540)aspartic-type endopeptidase inhibitor activity (GO:0019828)aspartic-type endopeptidase inhibitor activity (GO:0019828)aspartic-type endopeptidase inhibitor activity (GO:0019828)cargo receptor activity (GO:0038024)cargo receptor activity (GO:0038024)cell migration (GO:0016477)cell surface (GO:0009986)cytosol (GO:0005829)diet induced thermogenesis (GO:0002024)diet induced thermogenesis (GO:0002024)early endosome (GO:0005769)early endosome (GO:0005769)early endosome membrane (GO:0031901)early endosome membrane (GO:0031901)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)endosome (GO:0005768)endosome membrane (GO:0010008)endosome membrane (GO:0010008)endosome to plasma membrane protein transport (GO:0099638)extracellular exosome (GO:0070062)extracellular region (GO:0005576)extracellular region (GO:0005576)insulin receptor recycling (GO:0038020)insulin receptor recycling (GO:0038020)low-density lipoprotein particle binding (GO:0030169)low-density lipoprotein particle receptor activity (GO:0005041)low-density lipoprotein particle receptor activity (GO:0005041)lysosomal protein catabolic process (GO:1905146)lysosome (GO:0005764)membrane (GO:0016020)membrane (GO:0016020)membrane (GO:0016020)multivesicular body (GO:0005771)multivesicular body (GO:0005771)multivesicular body membrane (GO:0032585)negative regulation of BMP signaling pathway (GO:0030514)negative regulation of BMP signaling pathway (GO:0030514)negative regulation of amyloid precursor protein catabolic process (GO:1902992)negative regulation of amyloid precursor protein catabolic process (GO:1902992)negative regulation of amyloid precursor protein catabolic process (GO:1902992)negative regulation of amyloid-beta formation (GO:1902430)negative regulation of amyloid-beta formation (GO:1902430)negative regulation of amyloid-beta formation (GO:1902430)negative regulation of cytokine-mediated signaling pathway (GO:0001960)negative regulation of neurofibrillary tangle assembly (GO:1902997)negative regulation of neurofibrillary tangle assembly (GO:1902997)negative regulation of neurogenesis (GO:0050768)negative regulation of neurogenesis (GO:0050768)negative regulation of protein-containing complex assembly (GO:0031333)negative regulation of triglyceride catabolic process (GO:0010897)negative regulation of triglyceride catabolic process (GO:0010897)neuronal cell body (GO:0043025)neuropeptide binding (GO:0042923)neuropeptide signaling pathway (GO:0007218)nuclear envelope lumen (GO:0005641)nuclear envelope lumen (GO:0005641)perinucleolar compartment (GO:0097356)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of ER to Golgi vesicle-mediated transport (GO:1902953)positive regulation of adipose tissue development (GO:1904179)positive regulation of adipose tissue development (GO:1904179)positive regulation of endocytic recycling (GO:2001137)positive regulation of glial cell-derived neurotrophic factor production (GO:1900168)positive regulation of glial cell-derived neurotrophic factor production (GO:1900168)positive regulation of insulin receptor signaling pathway (GO:0046628)positive regulation of insulin receptor signaling pathway (GO:0046628)positive regulation of protein catabolic process (GO:0045732)positive regulation of protein localization to early endosome (GO:1902966)post-Golgi vesicle-mediated transport (GO:0006892)post-Golgi vesicle-mediated transport (GO:0006892)protein binding (GO:0005515)protein localization to Golgi apparatus (GO:0034067)protein retention in Golgi apparatus (GO:0045053)protein retention in Golgi apparatus (GO:0045053)protein retention in Golgi apparatus (GO:0045053)protein targeting (GO:0006605)protein targeting (GO:0006605)protein targeting (GO:0006605)protein targeting to lysosome (GO:0006622)protein targeting to lysosome (GO:0006622)protein transporter activity (GO:0140318)receptor-mediated endocytosis (GO:0006898)receptor-mediated endocytosis (GO:0006898)recycling endosome (GO:0055037)recycling endosome membrane (GO:0055038)regulation of smooth muscle cell migration (GO:0014910)retrograde transport, endosome to Golgi (GO:0042147)small GTPase binding (GO:0031267)trans-Golgi network (GO:0005802)transmembrane signaling receptor activity (GO:0004888)transport vesicle membrane (GO:0030658)

Expression (TPM)

TFs regulating SORL1 0 TFs

Transcription factors with Perturb-seq knockdown data for SORL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SORL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SORL1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SORL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr11:121,245,998–121,246,994	206.0 kb	Distal (>10kb) Multiome	99
	chr11:121,282,691–121,283,424	169.2 kb	Distal (>10kb) Multiome	96
	chr11:121,292,065–121,293,479	159.6 kb	Distal (>10kb) Multiome	859
	chr11:121,372,629–121,373,421	79.3 kb	Distal (>10kb) Multiome	106
	chr11:121,451,709–121,452,820	38 bp	At TSS Multiome	653
	chr11:121,479,068–121,480,080	27.2 kb	Distal (>10kb) Multiome	154
	chr11:121,655,309–121,656,263	203.5 kb	Distal (>10kb) Multiome	722
	chr11:121,722,316–121,723,780	270.6 kb	Distal (>10kb) Multiome	681
	chr11:122,512,671–122,513,278	1060.6 kb	Distal (>10kb) Multiome HiCAR	66

Genome Browser

Genomic view of the SORL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.