DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the DNA methylation process and gene activation. [provided by RefSeq, Sep 2015]
Transcription factors with Perturb-seq knockdown data for TET1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TET1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TET1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:68,271,165–68,272,025 | 288.8 kb | Distal (>10kb) Multiome | 177 | |
| chr10:68,331,343–68,333,064 | 227.3 kb | Distal (>10kb) Multiome | 1174 | |
| chr10:68,406,245–68,407,662 | 153.1 kb | Distal (>10kb) Multiome | 898 | |
| chr10:68,471,473–68,472,528 | 88.4 kb | Distal (>10kb) Multiome | 831 | |
| chr10:68,527,011–68,528,012 | 32.8 kb | Distal (>10kb) Multiome | 912 | |
| chr10:68,550,837–68,551,083 | 9.3 kb | Proximal (<10kb) | 244 | |
| chr10:68,559,963–68,561,065 | 29 bp | At TSS Multiome | 777 | |
| chr10:68,561,363–68,561,757 | 1.0 kb | Proximal (<10kb) | 352 | |
| chr10:68,561,916–68,562,412 | 1.6 kb | Proximal (<10kb) | 281 | |
| chr10:68,562,665–68,562,858 | 2.3 kb | Proximal (<10kb) | 181 | |
| chr10:68,563,128–68,563,333 | 2.8 kb | Proximal (<10kb) | 223 | |
| chr10:68,600,036–68,600,760 | 40.1 kb | Distal (>10kb) Multiome | 755 | |
| chr10:68,720,659–68,721,908 | 160.8 kb | Distal (>10kb) Multiome | 939 | |
| chr10:68,826,917–68,827,679 | 267.0 kb | Distal (>10kb) Multiome | 577 |
Genomic view of the TET1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.