Predicted to enable RNA binding activity. Involved in RNA catabolic process; RNA processing; and positive regulation of cell growth. Located in cytosol; nucleolus; and nucleoplasm. Part of nuclear exosome (RNase complex). Implicated in short stature, hearing loss, retinitis pigmentosa, and distinctive facies. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EXOSC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EXOSC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EXOSC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:130,433,040–130,433,900 | 260.3 kb | Distal (>10kb) Multiome | 543 | |
| chr9:130,444,394–130,446,012 | 249.0 kb | Distal (>10kb) Multiome | 568 | |
| chr9:130,446,125–130,446,731 | 247.3 kb | Distal (>10kb) Multiome | 326 | |
| chr9:130,578,979–130,579,997 | 114.3 kb | Distal (>10kb) Multiome | 855 | |
| chr9:130,663,509–130,664,148 | 29.7 kb | Distal (>10kb) Multiome | 159 | |
| chr9:130,681,081–130,682,308 | 12.3 kb | Distal (>10kb) Multiome | 836 | |
| chr9:130,689,990–130,690,532 | 3.6 kb | Proximal (<10kb) Multiome | 331 | |
| chr9:130,692,215–130,692,841 | 1.3 kb | Proximal (<10kb) Multiome | 141 | |
| chr9:130,693,327–130,694,076 | 12 bp | At TSS Multiome | 752 | |
| chr9:130,701,145–130,701,333 | 7.4 kb | Proximal (<10kb) | 249 | |
| chr9:130,712,289–130,713,655 | 19.0 kb | Distal (>10kb) Multiome | 791 | |
| chr9:130,834,623–130,835,640 | 141.4 kb | Distal (>10kb) Multiome | 715 | |
| chr9:130,940,926–130,941,385 | 247.5 kb | Distal (>10kb) Multiome HiCAR | 359 | |
| chr9:130,998,218–130,998,819 | 304.7 kb | Distal (>10kb) Multiome HiCAR | 380 | |
| chr9:131,008,758–131,009,603 | 315.4 kb | Distal (>10kb) Multiome HiCAR | 393 |
Genomic view of the EXOSC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.