This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for VDAC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VDAC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VDAC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:73,873,847–73,875,246 | 1336.0 kb | Distal (>10kb) Multiome HiCAR | 654 | |
| chr10:74,921,339–74,922,280 | 288.8 kb | Distal (>10kb) Multiome | 350 | |
| chr10:75,043,531–75,044,056 | 166.9 kb | Distal (>10kb) Multiome | 156 | |
| chr10:75,058,930–75,059,944 | 151.1 kb | Distal (>10kb) Multiome | 137 | |
| chr10:75,079,403–75,080,508 | 130.8 kb | Distal (>10kb) Multiome | 189 | |
| chr10:75,099,885–75,100,763 | 110.5 kb | Distal (>10kb) Multiome | 419 | |
| chr10:75,111,043–75,112,358 | 99.2 kb | Distal (>10kb) Multiome | 857 | |
| chr10:75,188,012–75,188,453 | 22.4 kb | Distal (>10kb) Multiome | 268 | |
| chr10:75,206,644–75,207,978 | 3.2 kb | Proximal (<10kb) Multiome | 207 | |
| chr10:75,209,910–75,211,260 | 68 bp | At TSS Multiome | 1059 | |
| chr10:75,233,116–75,236,429 | 25.4 kb | Distal (>10kb) Multiome | 1015 | |
| chr10:75,294,540–75,295,659 | 84.5 kb | Distal (>10kb) Multiome | 702 | |
| chr10:75,395,145–75,397,482 | 186.6 kb | Distal (>10kb) Multiome | 341 | |
| chr10:75,398,678–75,400,431 | 189.3 kb | Distal (>10kb) Multiome | 501 | |
| chr10:75,400,704–75,404,045 | 191.5 kb | Distal (>10kb) Multiome | 978 | |
| chr10:75,404,151–75,405,735 | 194.5 kb | Distal (>10kb) Multiome | 760 | |
| chr10:75,408,986–75,410,039 | 198.8 kb | Distal (>10kb) Multiome | 639 | |
| chr10:75,417,113–75,418,105 | 207.1 kb | Distal (>10kb) Multiome | 296 |
Genomic view of the VDAC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.