The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for GSTO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GSTO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GSTO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:103,917,536–103,919,139 | 335.8 kb | Distal (>10kb) Multiome HiCAR | 926 | |
| chr10:103,966,618–103,967,712 | 287.0 kb | Distal (>10kb) Multiome | 758 | |
| chr10:104,045,227–104,046,125 | 208.6 kb | Distal (>10kb) Multiome HiCAR | 116 | |
| chr10:104,057,535–104,058,241 | 196.2 kb | Distal (>10kb) Multiome HiCAR | 66 | |
| chr10:104,120,766–104,122,782 | 132.2 kb | Distal (>10kb) Multiome | 959 | |
| chr10:104,155,284–104,156,268 | 98.3 kb | Distal (>10kb) Multiome | 175 | |
| chr10:104,231,576–104,232,903 | 21.8 kb | Distal (>10kb) Multiome | 777 | |
| chr10:104,252,389–104,254,221 | 787 bp | At TSS Multiome | 583 | |
| chr10:104,254,370–104,255,379 | 728 bp | At TSS Multiome | 714 | |
| chr10:104,268,486–104,269,500 | 14.9 kb | Distal (>10kb) Multiome | 569 | |
| chr10:104,274,546–104,275,629 | 20.8 kb | Distal (>10kb) Multiome | 513 | |
| chr10:104,291,224–104,291,975 | 37.4 kb | Distal (>10kb) Multiome | 512 | |
| chr10:104,305,412–104,306,052 | 51.6 kb | Distal (>10kb) Multiome | 394 | |
| chr10:104,328,024–104,329,489 | 74.7 kb | Distal (>10kb) Multiome | 537 | |
| chr10:104,331,220–104,332,050 | 77.4 kb | Distal (>10kb) Multiome | 374 | |
| chr10:104,337,560–104,339,351 | 84.3 kb | Distal (>10kb) Multiome | 762 | |
| chr10:104,353,170–104,354,177 | 99.5 kb | Distal (>10kb) Multiome | 470 | |
| chr10:104,473,780–104,474,540 | 219.8 kb | Distal (>10kb) Multiome | 58 | |
| chr10:104,496,707–104,497,286 | 242.9 kb | Distal (>10kb) Multiome | 14 |
Genomic view of the GSTO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.