This gene encodes the A subunit of lactate dehydrogenase enzyme which catalyzes the reversible conversion of pyruvate to lactate with the concomitant oxidation of NADH to NAD in anaerobic glycolysis. The protein is found predominantly in skeletal muscle and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2023]
Transcription factors with Perturb-seq knockdown data for LDHA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LDHA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LDHA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:18,105,744–18,106,263 | 288.5 kb | Distal (>10kb) Multiome | 873 | |
| chr11:18,318,016–18,318,522 | 76.3 kb | Distal (>10kb) Multiome | 49 | |
| chr11:18,321,766–18,322,926 | 72.2 kb | Distal (>10kb) Multiome | 1044 | |
| chr11:18,393,759–18,396,665 | 1.6 kb | Proximal (<10kb) Multiome | 1203 | |
| chr11:18,526,292–18,527,325 | 132.3 kb | Distal (>10kb) Multiome | 1012 | |
| chr11:18,588,293–18,589,047 | 194.1 kb | Distal (>10kb) Multiome | 837 | |
| chr11:18,633,863–18,635,078 | 240.0 kb | Distal (>10kb) Multiome | 834 |
Genomic view of the LDHA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.