This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle, heart and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A retroprocessed pseudogene of this locus has been identified on chromosome 1. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for SELENOW. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SELENOW upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SELENOW, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:47,479,940–47,480,772 | 298.5 kb | Distal (>10kb) Multiome | 147 | |
| chr19:47,483,636–47,484,543 | 294.5 kb | Distal (>10kb) Multiome | 841 | |
| chr19:47,514,152–47,515,901 | 263.4 kb | Distal (>10kb) Multiome | 895 | |
| chr19:47,600,223–47,600,983 | 178.2 kb | Distal (>10kb) Multiome | 807 | |
| chr19:47,607,980–47,609,479 | 169.9 kb | Distal (>10kb) Multiome | 832 | |
| chr19:47,647,803–47,648,987 | 130.2 kb | Distal (>10kb) Multiome | 693 | |
| chr19:47,697,956–47,698,391 | 80.5 kb | Distal (>10kb) Multiome | 453 | |
| chr19:47,729,949–47,730,505 | 48.5 kb | Distal (>10kb) Multiome | 425 | |
| chr19:47,743,369–47,743,911 | 35.0 kb | Distal (>10kb) Multiome | 929 | |
| chr19:47,745,136–47,745,915 | 33.1 kb | Distal (>10kb) Multiome | 784 | |
| chr19:47,765,762–47,766,380 | 12.6 kb | Distal (>10kb) Multiome | 296 | |
| chr19:47,770,120–47,770,789 | 8.2 kb | Proximal (<10kb) Multiome | 127 | |
| chr19:47,778,102–47,779,241 | 136 bp | At TSS Multiome | 845 | |
| chr19:47,788,509–47,789,220 | 10.1 kb | Distal (>10kb) Multiome | 365 | |
| chr19:47,790,277–47,790,794 | 11.8 kb | Distal (>10kb) Multiome | 275 | |
| chr19:47,848,678–47,850,092 | 71.2 kb | Distal (>10kb) Multiome | 398 | |
| chr19:47,863,487–47,864,048 | 85.0 kb | Distal (>10kb) Multiome | 384 | |
| chr19:47,891,593–47,892,745 | 113.6 kb | Distal (>10kb) Multiome | 522 |
Genomic view of the SELENOW locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.