Enables GTPase binding activity and protein-membrane adaptor activity. Contributes to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including cholesterol homeostasis; positive regulation of TORC1 signaling; and regulation of cholesterol transport. Located in lysosome. Part of FNIP-folliculin RagC/D GAP. Is active in Ragulator complex and lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for LAMTOR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LAMTOR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LAMTOR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:71,928,161–71,929,328 | 174.4 kb | Distal (>10kb) Multiome | 869 | |
| chr11:72,040,697–72,041,585 | 62.3 kb | Distal (>10kb) Multiome | 586 | |
| chr11:72,080,144–72,081,188 | 22.6 kb | Distal (>10kb) Multiome | 789 | |
| chr11:72,088,078–72,088,746 | 15.0 kb | Distal (>10kb) Multiome | 50 | |
| chr11:72,102,846–72,104,062 | 80 bp | At TSS Multiome | 870 | |
| chr11:72,111,979–72,113,129 | 9.3 kb | Proximal (<10kb) Multiome | 901 | |
| chr11:72,222,505–72,225,138 | 120.1 kb | Distal (>10kb) Multiome | 815 | |
| chr11:72,237,525–72,239,038 | 135.0 kb | Distal (>10kb) Multiome | 427 | |
| chr11:72,239,350–72,240,441 | 136.6 kb | Distal (>10kb) Multiome | 349 | |
| chr11:72,243,706–72,244,831 | 141.0 kb | Distal (>10kb) Multiome | 234 |
Genomic view of the LAMTOR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.